Yes – you can execute native Apps Script with Office 365 back end

gas-fakes emulates the Google Apps Script (GAS) environment natively within a Node.js runtime. By translating standard GAS service calls into granular API requests, it provides a high-fidelity, local sandbox for debugging, automated testing, and execution without the constraints of the Google Cloud IDE. Microsoft as an Apps Script backend Apps Script: A ‘Lingua Franca’ for the Multi-Cloud Era introduces the concept of replacing Apps Script's regular Workspace backend with ksuite. You write Apps Script code as normal, but behind the scenes gas-fakes translates the code into ksuite API requests. I’m now adding the Microsoft Graph (Msgraph) backend. This represents a strategic evolution for the project. This addition allows developers to apply the familiar Apps Script programming model directly to the Microsoft 365 ecosystem. By acting as a “lingua franca” for workspace platforms, gas-fakes enables you to treat the underlying productivity suite as a pluggable component. This allows for th