The 10 Most Dangerous Herb-Drug Combinations (Data from 592 Interactions)

I maintain a database of 592 herb-drug interactions classified by severity. Of those, 84 are classified as "alta" (high severity) — meaning they can cause serious harm or death. Here are the 10 most dangerous medicinal herbs based on their interaction profiles. The Data From 592 total interactions: High severity (alta): 84 (14.2%) → Potentially life-threatening Moderate (moderada): 288 (48.6%) → Clinically significant Low (baja): 220 (37.2%) → Minor, usually manageable 84 combinations that can kill you. That's 1 in 7 herb-drug interactions in our database. The Top 10 Most Dangerous Herbs Ranked by number of high-severity drug interactions: 1. St. John's Wort (Hypericum perforatum) — 11 high-severity interactions The undisputed king of dangerous herb-drug interactions. St. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein — the same enzyme system that metabolizes roughly half of all prescription drugs. Life-threatening combinations: + Warfarin (anticoagulants): Reduces warfar